Effect of apelin on cardiac contractility in acute renovascular hypertension: The role of apelin receptor and kappa opioid receptor heterodimerization

Effect of apelin on cardiac contractility in acute renovascular hypertension: The role of apelin receptor and kappa opioid receptor heterodimerization


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دانشگاه علوم پزشکی کرمان
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نویسندگان: محبوبه یگانه حاج احمدی , حمید نجفی پور , فرزانه رستم زاده , سیاوش جوکار

کلمات کلیدی: apelin receptors; dimerization; myocardium; opioid receptors; reno-vascular hypertension

نشریه: 16525 , 12 , 21 , 2018

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کد مقاله 97001233
عنوان فارسی مقاله Effect of apelin on cardiac contractility in acute renovascular hypertension: The role of apelin receptor and kappa opioid receptor heterodimerization
عنوان لاتین مقاله Effect of apelin on cardiac contractility in acute renovascular hypertension: The role of apelin receptor and kappa opioid receptor heterodimerization
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نوع مقاله Original Article
نحوه ایندکس شدن مقاله ISI - Web of Science – JCR
آدرس لینک مقاله/ همایش در شبکه اینترنت http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=1&SID=F4szZyoQpLTmixiyomX&page=1&doc=1

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Objective: Apelin/APJ system plays an important role in the regulation of myocardial contractility (MC) and blood pressure. Opioid receptors (OPRs) are also important cardiovascular regulators and exert many of their effects through modulating the function of other systems. This study analyzed the interaction between APJ and kappa OPRs (KOR) in cardiac responsiveness to apelin in acute reno-vascular hypertension (2K1C). Materials and methods: MC studies were carried out on 2K1C rats. F13A (APJ blocker), Naloxone (OPR inhibitor), nor-BNI (kappa OPR inhibitor), PTX (Gi path inhibitor) and chelerytrine (PKC inhibitor) were administered prior to apelin 20 and 40 μg/kg. The phosphorylation of ERK1/2 (PERK) was also assessed. Dimerization of APJ and KOR was evaluated by immunoprecipitation. Results: Both doses of apelin reduced blood pressure. Apelin40 exerted a negative inotropic effect which was inhibited by norBNI, but apelin20 showed a positive inotropic effect which was resistant to this inhibition. Hypertension increased the heterodimerization of the APJ and KOR and this was reduced by apelin20. F13A, naloxone and PTX significantly reduced PERK in apelin40 group but F13A, naloxone, and chelerytrine significantly increased PERK in the apelin20 group. Conclusion: The lowering effect of apelin40 on MC and its non-effectiveness on APJ/KOR dimerization, while apelin20 augmented contractility and reduced dimerization, implies the APJ/KOR related effects of apelin on the MC under acute renovascular hypertension. This may have potential clinical applications as apelin has been introduced as a potential therapeutic agent in heart failure and opioids are being currently used in the treatment of myocardial infarction.

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نویسنده نفر چندم مقاله
محبوبه یگانه حاج احمدیاول
حمید نجفی پوردوم
فرزانه رستم زادهسوم
سیاوش جوکارپنجم

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IJBMS_Volume 21_Issue 12_Pages 1305-1315.pdf1397/08/191100074دانلود