Circulating Levels of Interleukin-35 in Patients with Multiple Sclerosis: Evaluation of the Influences of FOXP3 Gene Polymorphism and Treatment Program

Circulating Levels of Interleukin-35 in Patients with Multiple Sclerosis: Evaluation of the Influences of FOXP3 Gene Polymorphism and Treatment Program


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دانشگاه علوم پزشکی کرمان
دانشگاه علوم پزشکی کرمان

نویسندگان: حسینعلی ابراهیمی میمند , عبداله جعفرزاده , حمید نجفی پور , مریم نعمتی , حمید دانشور , - عضو هیات علمی علوم پزشکی کرمان - , - عضو هیات علمی علوم پزشکی کرمان - , - دانشجو اول علوم پزشکی کرمان - , - دانشجو دوم علوم پزشکی کرمان - , محمد مهدی محمدی

کلمات کلیدی: Multiple sclerosis . IL-35 . FOXP3 . Gene polymorphism . Treatment

نشریه: 18110 , 4 , 55 , 2015

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کد مقاله 95000595
عنوان فارسی مقاله Circulating Levels of Interleukin-35 in Patients with Multiple Sclerosis: Evaluation of the Influences of FOXP3 Gene Polymorphism and Treatment Program
عنوان لاتین مقاله Circulating Levels of Interleukin-35 in Patients with Multiple Sclerosis: Evaluation of the Influences of FOXP3 Gene Polymorphism and Treatment Program
ناشر Springer New York LLC journals@springer-sbm.com
آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ خیر
عنوان نشریه (خارج از لیست فوق) Journal of Molecular Neuroscience
نوع مقاله Original Article
نحوه ایندکس شدن مقاله ISI - Web of Science – JCR
آدرس لینک مقاله/ همایش در شبکه اینترنت https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84925485069&origin=inward

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Abstract The regulatory T (Treg) cells play a major role in the control of the autoimmunity and inflammation, and IL-35 has been described as an immunosuppressive cytokine that is mainly produced by CD4+ FOXP3+ Treg cells. The aim of this study was to evaluate the serum levels of IL-35 and a single nucleotide polymorphism (SNP), rs3761548, in FOXP3 gene in patients with multiple sclerosis. The blood samples were collected from 140 multiple sclerosis (MS) patients (including 51 untreated and 89 treated patients) and 140 healthy subjects as a control group. The serum levels of IL-35 were measured by ELISA. The DNA was analyzed for SNP rs3761548 in FOXP3 gene using SSP-PCR. There was no significant difference between untreated MS patients and control group regarding the mean serum levels of IL-35, although this parameter was higher in untreated patients. However, the mean serum level of IL-35 in treated MS patients was significantly higher than that in the control group (P<0.008). The mean serum levels of IL-35 in patients who were treated with interferon-β, methylprednisolone, or with the both interferon-β and methylprednisolone were significantly higher than that in the healthy group (P<0.01, P<0.01, and P<0.2, respectively). The frequencies of AA and AC genotypes at rs3761548 in the FOXP3 gene were significantly higher in MS group as compared with healthy subjects (P<0.05). The frequency of CC genotype at rs3761548 was significantly lower in the MS group in comparison with healthy control subjects (P<0.001). Moreover, the frequency of A allele was significantly higher whereas the frequency of C allele was significantly lower in MS patients in comparison to healthy subjects (P<0.001). The mean serum level of IL-35 was significantly lower in MS patients or healthy subjects with AA genotype as compared with those with CC genotype at rs3761548 in FOXP3 gene (P<0.01 and P<0.001, respectively). These results showed higher serum levels of IL-35 in treated MS patients representing that the benefit effects of treatment may in part performed through the upregulation of the IL-35 production. The SNP rs3761548 may influence the susceptibility to MS disease and the serum levels of IL-35.

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نویسنده نفر چندم مقاله
حسینعلی ابراهیمی میمندچهارم
عبداله جعفرزادهاول
حمید نجفی پورهشتم
مریم نعمتیهفتم
حمید دانشوریازدهم
- عضو هیات علمی علوم پزشکی کرمان -دوم
- عضو هیات علمی علوم پزشکی کرمان -سوم
- دانشجو اول علوم پزشکی کرمان -پنجم
- دانشجو دوم علوم پزشکی کرمان -ششم
محمد مهدی محمدیدهم

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نام فایل تاریخ درج فایل اندازه فایل دانلود
10.1007_s12031-014-0443-z.pdf1396/04/15176401دانلود